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Primidone is classified as a Schedule IV controlled substance by the Drug Enforcement Administration (DEA). This means that it has potential for abuse, but less than other drugs classified higher on the DEA s list. The list shows each drug s respective classifications under both the Misuse of Drugs Act 2024 and the Misuse of Drugs Regulations 2024. The list is not exhaustive and, in the event of a primidone controlled substance Therapeutic drug monitoring For primidone Monitor plasma concentrations of derived phenobarbital; plasma concentration for optimum response is 15 40 mg/litre (60 180 micromol/litre). Treatment cessation A randomized, controlled trial w found that primidone was more likely to cause impotence than phenytoin, carbamazepine, or phenobarbital. Like phenytoin, primidone is rarely associated with lymphadenopathy. Primidone can also cause vomiting; this happens in 1.0тАУ0.1% of users. See more MYSOLINE, used alone or concomitantly with other anticonvulsants, is indicated in the control of grand mal, psychomotor, and focal epileptic seizures. It may control grand